BDBM372066 3-(5-Chloro-2-fluoro-4-methyl-phenyl)-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triaza-spiro[4.5]decan-4-one::US10239876, Example 89::US10435407, Example 89

SMILES Cc1cc(F)c(cc1Cl)N1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O

InChI Key InChIKey=VHCMXRIIELUJEM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372066   

TargetD(1A) dopamine receptor(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 372066BDBM372066(3-(5-Chloro-2-fluoro-4-methyl-phenyl)-1-phenyl-8-(...)
Affinity DataIC50: 2.29E+3nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 372066BDBM372066(3-(5-Chloro-2-fluoro-4-methyl-phenyl)-1-phenyl-8-(...)
Affinity DataIC50: 2.29E+3nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent