BDBM372083 3-[(+)-2-Oxo-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one::US10239876, Example 106::US10435407, Example 106

SMILES O=C(c1cnc2[nH]ncc2c1)N1CCC2(CC1)C(=O)N([C@@H]1CCN(CC(F)(F)F)C1=O)CN2c1ccccc1

InChI Key InChIKey=QGAZPZGGCFPPIQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372083   

TargetD(1A) dopamine receptor(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 372083BDBM372083(3-[(+)-2-Oxo-1-(2,2,2-trifluoroethyl)pyrrolidin-3-...)
Affinity DataIC50: 80.7nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 372083BDBM372083(3-[(+)-2-Oxo-1-(2,2,2-trifluoroethyl)pyrrolidin-3-...)
Affinity DataIC50: 80.7nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent