BDBM377712 5-amino-1-[1-(cyanomethyl)piperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide::US10266513, Example 6::US10815213, Example 6

SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC#N)CC1

InChI Key InChIKey=PGGNSEQKBUZEDP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377712   

TargetTyrosine-protein kinase BTK(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 377712BDBM377712(US10266513, Example 6 | 5-amino-1-[1-(cyanomethyl)...)
Affinity DataIC50: 11.7nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 377712BDBM377712(US10266513, Example 6 | 5-amino-1-[1-(cyanomethyl)...)
Affinity DataIC50: 11.7nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent