BDBM377789 5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-difluorobenzyl)phenyl]-1H-pyrazole-4-carboxamide::US10266513, Example 83::US10266513, Example 84::US10266513, Example 85::US10815213, Example 85

SMILES NC(=O)c1c(N)n(nc1-c1ccc(Cc2ccc(F)c(F)c2)cc1)C1CCCN(C1)C#N

InChI Key InChIKey=VDBOXQIBFBZBCM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 377789   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377789(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-difluo...)
Affinity DataIC50:  15.3nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377789(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-difluo...)
Affinity DataIC50:  5.60nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377789(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-difluo...)
Affinity DataIC50:  212nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377789(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-difluo...)
Affinity DataIC50:  15.3nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377789(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-difluo...)
Affinity DataIC50:  5.60nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377789(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(3,4-difluo...)
Affinity DataIC50:  212nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent