BDBM398664 1-(3-(cyanomethoxy)- 4-methyl-1-phenyl-1H- pyrazol-5-yl)-3-((3S,4R)- 4-(3,4-difluorophenyl)- 1-(2-methoxyethyl) pyrrolidin-3-yl)urea::US10323022, Example 141

SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(OCC#N)nn2-c2ccccc2)[C@@H](C1)c1ccc(F)c(F)c1

InChI Key InChIKey=SFLUIEOIUWUKLG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398664   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 398664BDBM398664(1-(3-(cyanomethoxy)- 4-methyl-1-phenyl-1H- pyrazol...)
Affinity DataIC50: 100nMAssay Description:Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent