BDBM400159 N-(3,4-difluorophenyl)-6-methyl-7-(2-(((1r,3r)-3-methyl-1-oxidothietan-3-yl)amino)-2-oxoacetyl)-2,3-dihydro-1H-pyrrolizine-5-carboxamide::US10328053, Compound 151::US10874640, Compound 151::US20230270719, Compound 151

SMILES Cc1c(C(=O)C(=O)N[C@@]2(C)C[S@](=O)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1

InChI Key InChIKey=HIXLPXCVOTTYCF-JUKHWHIISA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400159   

TargetSodium/bile acid cotransporter(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM400159(N-(3,4-difluorophenyl)-6-methyl-7-(2-(((1r,3r)-3-m...)
Affinity DataEC50:  30.6nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/bile acid cotransporter(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM400159(N-(3,4-difluorophenyl)-6-methyl-7-(2-(((1r,3r)-3-m...)
Affinity DataEC50:  30.6nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus genotype C subtype ayr (isolate ...)
Gilead Sciences

US Patent
LigandPNGBDBM400159(N-(3,4-difluorophenyl)-6-methyl-7-(2-(((1r,3r)-3-m...)
Affinity DataEC50:  30.6nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent