BDBM400894 2-amino-N-{4-[(3S,5R)-3-amino-5- (trifluoromethyl)piperidin-1-yl]pyridin-3- yl}-6-trifluoromethyl-furo[3,2-b]pyridine- 3-carboxamide::US10000507, Example 61

SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NC(=O)c1c(N)oc2cc(cnc12)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=NIDXDGAWKVAEJZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400894   

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 400894BDBM400894(2-amino-N-{4-[(3S,5R)-3-amino-5- (trifluoromethyl)...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 400894BDBM400894(2-amino-N-{4-[(3S,5R)-3-amino-5- (trifluoromethyl)...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 400894BDBM400894(2-amino-N-{4-[(3S,5R)-3-amino-5- (trifluoromethyl)...)
Affinity DataIC50: 55nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent