BDBM404378 N-(isoxazolo[5,4-b]pyridin-3-yl)-2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetamide::USRE46942, Example 38

SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2noc3ccccc23)C1=O

InChI Key InChIKey=ZLQJPCTWFZHULT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404378   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 404378BDBM404378(N-(isoxazolo[5,4-b]pyridin-3-yl)-2-(3-(4-(4-methox...)
Affinity DataIC50: 4.56E+3nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 404378BDBM404378(N-(isoxazolo[5,4-b]pyridin-3-yl)-2-(3-(4-(4-methox...)
Affinity DataIC50: 6.50E+3nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent