BDBM420283 alpha-ketoamide inhibitor 11r::med.21724, Compound 64

SMILES O=C(N[C@@H](CC1CCCCC1)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)C(=O)NCc1ccccc1)\C=C\c1ccccc1

InChI Key InChIKey=QTGORSKTHIBLJT-FIVJMQNTSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 420283   

TargetReplicase polyprotein 1ab [3264-3569](Severe acute respiratory syndrome coronavirus 2)
University Of Lubeck

LigandPNGBDBM420283(alpha-ketoamide inhibitor 11r | med.21724, Compoun...)
Affinity DataIC50:  180nMAssay Description:A fluorescent substrate harboring the cleavage site (indicated by the arrow, ↓) of SARS-CoV-2 Mpro(Dabcyl-KTSAVLQ↓SGFRKM-E(Edans)-NH2; GL...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Bonn

LigandPNGBDBM420283(alpha-ketoamide inhibitor 11r | med.21724, Compoun...)
Affinity DataIC50:  710nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM420283(alpha-ketoamide inhibitor 11r | med.21724, Compoun...)
Affinity DataIC50:  180nMAssay Description:Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM420283(alpha-ketoamide inhibitor 11r | med.21724, Compoun...)
Affinity DataIC50:  710nMAssay Description:Inhibition of SARS CoV-2 3CL proteaseMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM420283(alpha-ketoamide inhibitor 11r | med.21724, Compoun...)
Affinity DataIC50:  180nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM420283(alpha-ketoamide inhibitor 11r | med.21724, Compoun...)
Affinity DataIC50:  160nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed