BDBM444722 (E)-2-(2-((3-(4-(2-fluoro-3- methoxyphenoxy)phenyl)-7-methoxy-1H- pyrazolo[4,3-c]pyridin-1- yl)methyl)pyrrolidine-1-carbonyl)-4,4- dimethylpent-2-enenitrile::US10662187, Compound 92::US10793566, Compound 92

SMILES COc1cccc(Oc2ccc(cc2)-c2nn(CC3CCCN3C(=O)C(=C\C(C)(C)C)\C#N)c3c(OC)cncc23)c1F

InChI Key InChIKey=FHKZUOAKBFYREF-CJLVFECKSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444722   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444722((E)-2-(2-((3-(4-(2-fluoro-3- methoxyphenoxy)phenyl...)
Affinity DataIC50:  55nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zibo Biopolar Changsheng Pharmaceutical

US Patent
LigandPNGBDBM444722((E)-2-(2-((3-(4-(2-fluoro-3- methoxyphenoxy)phenyl...)
Affinity DataIC50:  55nMAssay Description:Measurements were performed in a reaction volume of 15 μL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 μM peptide subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent