BDBM456277 6-(4-(((1-hydroxy-1-(4- methyl-1-oxo-1,3- dihydroisobenzofuran-5- yl)propan-2- yl)amino)methyl)-1H- pyrazol-1-yl)-4- methylnicotinonitrile (Enantiomer-I)::US10723723, Example 176-I

SMILES CC(NCc1cnn(c1)-c1cc(C)c(cn1)C#N)C(O)c1ccc2C(=O)OCc2c1C

InChI Key InChIKey=MUQMFRIFLPZDLY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456277   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456277(6-(4-(((1-hydroxy-1-(4- methyl-1-oxo-1,3- dihydroi...)
Affinity DataIC50:  4nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent