BDBM463199 4-Amino-5-(4-chloro-5- hydroxypyridin-2-yl)-2-{8-[(2- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 104-B::US10780092, Example 53-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(Cl)c(O)cn1

InChI Key InChIKey=PIYZXACYQVVOAD-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463199   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463199(4-Amino-5-(4-chloro-5- hydroxypyridin-2-yl)-2-{8-[...)
Affinity DataKi:  1.08nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463199(4-Amino-5-(4-chloro-5- hydroxypyridin-2-yl)-2-{8-[...)
Affinity DataKi:  1.10nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent