BDBM463248 4-(4-Amino-5-methyl-6-oxo-2- {8-[(2,3,5- trifluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-6,7-dihydro- 5H-pyrro1o[2,3-d]pyrimidin-5- yl)-2-fluoro-6- hydroxybenzonitrile::US10780092, Example 102-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2F)n1)c1cc(O)c(C#N)c(F)c1

InChI Key InChIKey=WZMNHSDEFOKVCC-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463248   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463248(4-(4-Amino-5-methyl-6-oxo-2- {8-[(2,3,5- trifluoro...)
Affinity DataKi:  0.118nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent