BDBM463254 4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl- 2-{8-[(4-methylcyclo- hexyl)methyl]imidazo- [1,2-a]pyrazin-6-yl}-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 108-AA

SMILES CC1CCC(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(Cl)c(O)c2)CC1

InChI Key InChIKey=QQBSQFKKQZDELG-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463254   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463254(4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl- 2-...)
Affinity DataKi:  0.924nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent