BDBM463266 4-Amino-5-(4- hydroxypyridin-2-yl)- 2-(8-isopentyl-[1,2,4]- triazolo[1,5-a]pyrazin- 6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 119-B

SMILES CC(C)CCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)ccn1

InChI Key InChIKey=XXODUAHXSYVGFA-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463266   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463266(4-Amino-5-(4- hydroxypyridin-2-yl)- 2-(8-isopentyl...)
Affinity DataKi:  2.76nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent