BDBM463352 3-amino-N-[2-(3-chloro-5-methylphenoxy)ethyl]-1-({4-[(2-oxopyridin-1-::US10781181, Example 33

SMILES Cc1cc(Cl)cc(OCCNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N)c1

InChI Key InChIKey=MXRZHBPGBXCCGR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463352   

TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463352(3-amino-N-[2-(3-chloro-5-methylphenoxy)ethyl]-1-({...)
Affinity DataIC50: >4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25° C. with the fluoroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463352(3-amino-N-[2-(3-chloro-5-methylphenoxy)ethyl]-1-({...)
Affinity DataIC50:  114nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent