BDBM463835 8-(6-methyl-7-oxo-6,7-dihydro-1H- pyrazolo[3,4-c]pyridin-4-yl)-6- (methylsulfonyl)spiro[1,4-benzoxazine- 2,1'-cyclopropan]-3(4H)-one::US10781209, Example 65

SMILES CN1C(=O)C2(CCC2)Nc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ncc12)S(C)(=O)=O

InChI Key InChIKey=KJOYYMJUGLEAFU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463835   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM463835(8-(6-methyl-7-oxo-6,7-dihydro-1H- pyrazolo[3,4-c]p...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM463835(8-(6-methyl-7-oxo-6,7-dihydro-1H- pyrazolo[3,4-c]p...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent