BDBM464572 Preparation of N-((4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl)-1-(isopropylsulfonyl)-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)dihydroindole-4-carboxamide ::US10793549, Compound G-47

SMILES CC(C)S(=O)(=O)N1CCc2c1cc(cc2C(=O)NCc1c(C)cc(C)[nH]c1=O)-c1ccc(nc1)N1CCN(C)CC1

InChI Key InChIKey=MRSABGAGWFPBGX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464572   

TargetHistone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM464572(Preparation of N-((4, 6-dimethyl-2-oxo-1, 2-dihydr...)
Affinity DataIC50:  160nMAssay Description:Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent