BDBM466922 (3R)-4-[6-(1- Cyclopropanecarbonylpiperidin- 4-yl)-2-{1H-pyrrolo[2,3- b]pyridin-4-yl}pyrimidin-4- yl]-3-methylmorpholine::US10800774, Example 21

SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1CCN(CC1)C(=O)C1CC1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466922   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM466922((3R)-4-[6-(1- Cyclopropanecarbonylpiperidin- 4-yl)...)
Affinity DataIC50:  22nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM466922((3R)-4-[6-(1- Cyclopropanecarbonylpiperidin- 4-yl)...)
Affinity DataIC50:  82nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent