BDBM467824 N-(4-Cyano-1,4-oxazepan-6-yl)-5-(*S)-(2-methyl-4-phenoxyphenyl)- 4-oxo-4,5-dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2- carboxamide;::US10800792, Example 485::US10822348, Example 31

SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)NC4COCCN(C4)C#N)c([nH]c1=O)c23

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 467824   

TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467824(N-(4-Cyano-1,4-oxazepan-6-yl)-5-(*S)-(2-methyl-4-p...)
Affinity DataIC50:  20nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467824(N-(4-Cyano-1,4-oxazepan-6-yl)-5-(*S)-(2-methyl-4-p...)
Affinity DataIC50:  12.6nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467824(N-(4-Cyano-1,4-oxazepan-6-yl)-5-(*S)-(2-methyl-4-p...)
Affinity DataIC50:  12.6nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent