BDBM469209 8-[2-(cyclopropylmethoxy)-5- methylsulfonylphenyl]-1-fluoro-6-methyl-2,3- dihydro-1H-indolizin-5-one::US10807982, Example 90

SMILES Cc1cc(c2C(F)CCn2c1=O)-c1cc(ccc1OCC1CC1)S(C)(=O)=O

InChI Key InChIKey=JOLCHACIXYRIRA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 469209   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM469209(8-[2-(cyclopropylmethoxy)-5- methylsulfonylphenyl]...)
Affinity DataIC50: <500nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BREM was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent