BDBM473803 3-(1-Acetyl-1,2,3,4- tetrahydro-quinolin-6-yl)- 3,5,6,7-tetrahydro- benzoimidazol-4-one::US10858342, Compound C-AAF

SMILES CC(=O)N1CCCc2cc(ccc12)-n1cnc2CCCC(=O)c12

InChI Key InChIKey=NGUIQLILNOAVNO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473803   

TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473803(3-(1-Acetyl-1,2,3,4- tetrahydro-quinolin-6-yl)- 3,...)
Affinity DataIC50:  1.00E+7nMAssay Description:Assays are performed as for aldosterone synthase except for the use of 150 units of CYP11B1, 11-deoxycortisol as substrate and cortisol measured as p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473803(3-(1-Acetyl-1,2,3,4- tetrahydro-quinolin-6-yl)- 3,...)
Affinity DataIC50:  37nMAssay Description:Assays are performed in 96-well format in a final volume of 60 microL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent