BDBM474410 1,1,1,3,3,3-Hexafluoropropan-2-yl 2-benzoyl-2,8-diazaspiro[4.5]decane-8-carboxylate ::US10858373, Example 8

SMILES FC(F)(F)C(OC(=O)N1CCC2(CCN(C2)C(=O)c2ccccc2)CC1)C(F)(F)F

InChI Key InChIKey=FIVFLCJVHOGKLP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474410   

TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM474410(1,1,1,3,3,3-Hexafluoropropan-2-yl 2-benzoyl-2,8-di...)
Affinity DataIC50:  3.29nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMonoglyceride lipase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM474410(1,1,1,3,3,3-Hexafluoropropan-2-yl 2-benzoyl-2,8-di...)
Affinity DataIC50:  35nMAssay Description:Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent