BDBM475702 8a-ethyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- 1,2,3,4,4a,5,6, 8-octahydro- 2,7- naphthyridine::US10851116, Example Intermediate

SMILES CCC12CNCCC1CCN(C2)c1ncnc2[nH]ccc12

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475702   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475702(8a-ethyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- ...)
Affinity DataEC50:  16nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475702(8a-ethyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- ...)
Affinity DataEC50:  1.98E+3nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475702(8a-ethyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- ...)
Affinity DataEC50:  157nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM475702(8a-ethyl-7- (7H- pyrrolo[2,3- d]pyrimidin-4- yl)- ...)
Affinity DataEC50:  25nMAssay Description:Inhibition of phosphorylation of a synthetic peptide was measured in an HTRF-based assay using the TK substrate-Biotin from the Cisbio HTRFKinEASE TK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent