BDBM476461 (2S)-4-{(4S,5S)-5-[3- (aminomethyl)phenyl]-4-methyl-4,5- dihydro-1,3-oxazol-2-yl}-1-[N2- cyclohexyl-N6-(methylsulfonyl)-D- lysyl]-N-(thiophen-2- ylmethyl)piperazine-2-carboxamide::US10875851, Example 117

SMILES C[C@@H]1N=C(O[C@H]1c1cccc(CN)c1)N1CCN([C@@H](C1)C(=O)NCc1cccs1)C(=O)[C@@H](CCCCNS(C)(=O)=O)NC1CCCCC1

InChI Key InChIKey=UXWDRYOJFUAWSY-QIXIFPRPSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476461   

TargetCoagulation factor XII(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM476461((2S)-4-{(4S,5S)-5-[3- (aminomethyl)phenyl]-4-methy...)
Affinity DataIC50:  5.20nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent