BDBM477604 (R)—N-(1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-indazol-4-34)-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide::US10889564, Example 34

SMILES Cc1ccccc1-n1ncc2[C@@H](CCCc12)NC(=O)c1noc2CCCCc12

InChI Key InChIKey=HUVJSRAMULDASL-QGZVFWFLSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 477604   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477604((R)—N-(1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  3nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477604((R)—N-(1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate in presence of 2 nM of DHODH by DCIP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics

US Patent
LigandPNGBDBM477604((R)—N-(1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-in...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed