BDBM477909 (E)-3-((1R,5S,6S)-3-amino-5-(5-((5-cyanopyridin-2-yl)ethynyl)-2-fluorophenyl)-5-(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-1-yl)-N,N-dimethylacrylamide::US10889581, Example 112

SMILES CN(C)C(=O)\C=C\[C@]12C[C@H]1[C@](CF)(N=C(N)S2)c1cc(ccc1F)C#Cc1ccc(cn1)C#N

InChI Key InChIKey=AOKKWUDSGZAXHM-HSWNYDEUSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 477909   

TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM477909((E)-3-((1R,5S,6S)-3-amino-5-(5-((5-cyanopyridin-2-...)
Affinity DataIC50:  25nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM477909((E)-3-((1R,5S,6S)-3-amino-5-(5-((5-cyanopyridin-2-...)
Affinity DataIC50:  1.76E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM477909((E)-3-((1R,5S,6S)-3-amino-5-(5-((5-cyanopyridin-2-...)
Affinity DataIC50:  1.59E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent