BDBM480448 (R)-4-(tert-butyl)-N-(8-(4-((1-methyl-1H-pyrazol-3-yl)amino)-1,3,5-triazin-2-yl)-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-5-yl)oxazole-2-carboxamide ::US10899753, Example 96

SMILES Cn1ccc(Nc2ncnc(n2)-c2ccc3[C@@H](CCN(CC(F)(F)F)Cc3c2)NC(=O)c2nc(co2)C(C)(C)C)n1

InChI Key InChIKey=SADDXAMAYPJECF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 480448   

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandChemical structure of BindingDB Monomer ID 480448BDBM480448((R)-4-(tert-butyl)-N-(8-(4-((1-methyl-1H-pyrazol-3...)
Affinity DataIC50: 5.5nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent