BDBM482168 4-{4-Amino-3-[3-(5-chloro-2-fluoro-4-methoxy-benzenesulfonylamino)-2-fluoro-phenyl]-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic acid tert-butyl ester ::US10918642, Cmpd # 10::US11491158, Cmpd 10

SMILES COc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(-c2nn(C3CCN(CC3)C(=O)OC(C)(C)C)c3ncnc(N)c23)c1F

InChI Key InChIKey=CSFPVSVEFSVXEL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482168   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 482168BDBM482168(US10918642, Cmpd # 10 | 4-{4-Amino-3-[3-(5-chloro-...)
Affinity DataIC50: 160nMAssay Description:Serially diluted compounds were incubated for 60 minutes at room temperature in the presence of ATP/P33 gammaATP mix, substrate and enzyme in a volum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3 [540-1115](Human)
Nerviano Medical Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 482168BDBM482168(US10918642, Cmpd # 10 | 4-{4-Amino-3-[3-(5-chloro-...)
Affinity DataIC50: 160nMAssay Description:The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent