BDBM482229 Cyclohexanesulfonic acid [3-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluoro-phenyl]-amide ::US10918642, Cmpd # 89::US11491158, Cmpd 89

SMILES Cn1cc(-c2cccc(NS(=O)(=O)C3CCCCC3)c2F)c2c(N)ncnc12

InChI Key InChIKey=TUYXBQNRMZCKPH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482229   

TargetEukaryotic translation initiation factor 2-alpha kinase 3 [540-1115](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM482229(Cyclohexanesulfonic acid [3-(4-amino-7-methyl-7H-p...)
Affinity DataIC50: >160nMAssay Description:The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM482229(Cyclohexanesulfonic acid [3-(4-amino-7-methyl-7H-p...)
Affinity DataIC50: >160nMAssay Description:Serially diluted compounds were incubated for 60 minutes at room temperature in the presence of ATP/P33 gammaATP mix, substrate and enzyme in a volum...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent