BDBM482795 US10919862, Example 2-6::[(1 S,5R)-1,3,3-trimethyl-5-(2-{[4-(trifluoromethoxy)phenyl]amino}-1H-imidazo-[4,5-c]pyridin-1-yl)cyclohexyl]methanol

SMILES CC1(C)C[C@H](C[C@@](C)(CO)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cnccc12

InChI Key InChIKey=VLSKRZTWOMQRGQ-OPAMFIHVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482795   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM482795(US10919862, Example 2-6 | [(1 S,5R)-1,3,3-trimethy...)
Affinity DataIC50:  1.60E+3nMAssay Description:Levels of (2R)-2-hydroxyglutarate (2HG) were measured in medium of a cell line with overexpression of mutated isocitrate dehydrogenase (mIDH) protein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM482795(US10919862, Example 2-6 | [(1 S,5R)-1,3,3-trimethy...)
Affinity DataIC50:  30nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent