BDBM483629 N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-yl]-N''-hydroxy-4-({2-[S-(2- hydroxypropyl)sulfonimidoyl]ethyl}amino)- 1,2,5-oxadiazole-3-carboximidamide (isomer 1)::US10927086, Example 84::US10927086, Example 85::US10927086, Example 86::US10927086, Example 87

SMILES CC(O)CS(=N)(=O)CCNc1nonc1\C(N[C@@H]1Cc2ccc(F)cc12)=N/O

InChI Key InChIKey=YMIBDYMKALKXMX-WBHVAOMPSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 483629   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483629(N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-...)
Affinity DataIC50:  56.8nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483629(N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-...)
Affinity DataIC50:  46.1nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483629(N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-...)
Affinity DataIC50:  47.4nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483629(N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-...)
Affinity DataIC50:  49.5nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent