BDBM50001532 CHEMBL3237447::US8841312, 188

SMILES N#Cc1nccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c12

InChI Key InChIKey=UOXNTMLLQKBLLA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50001532   

TargetCyclin-dependent kinase 6(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 50001532BDBM50001532(CHEMBL3237447 | US8841312, 188)
Affinity DataIC50: 13.4nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50001532BDBM50001532(CHEMBL3237447 | US8841312, 188)
Affinity DataIC50: 27nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 50001532BDBM50001532(CHEMBL3237447 | US8841312, 188)
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50001532BDBM50001532(CHEMBL3237447 | US8841312, 188)
Affinity DataIC50: 46nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50001532BDBM50001532(CHEMBL3237447 | US8841312, 188)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) using histone H1 as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed