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BDBM50015094 CHEMBL152665::N-Hydroxy-2-phenyl-acetamide::N-hydroxy-2-phenylacetamide::Phenylacetohydroxamic acid

SMILES: ONC(=O)Cc1ccccc1

InChI Key: InChIKey=FPOQLQZHRCEVOT-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50015094   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
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n/an/a 3.00E+5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)


J Med Chem 33: 992-8 (1990)


Article DOI: 10.1021/jm00165a017
BindingDB Entry DOI: 10.7270/Q2WW7GNM
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
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n/an/a 3.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against RBL-1 5-LO


J Med Chem 30: 574-80 (1987)


Article DOI: 10.1021/jm00386a022
BindingDB Entry DOI: 10.7270/Q2QN67BB
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
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n/an/a>3.33E+4n/an/an/an/an/a25



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of HDAC4 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...


J Med Chem 56: 1772-6 (2013)


Article DOI: 10.1021/jm301355j
BindingDB Entry DOI: 10.7270/Q2XK8GWB
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
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n/an/a 1.36E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at Pseudomonas aeruginosa LasB using Abz-Ala-Gly-Leu-Ala-p-Nitro-Benzyl-Amide as substrate incubated for 30 mins prior to substra...


ACS Med Chem Lett 3: 668-672 (2012)


BindingDB Entry DOI: 10.7270/Q2BG2RVM
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
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n/an/a 1.16E+4n/an/an/an/an/a25



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of HDAC8 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...


J Med Chem 56: 1772-6 (2013)


Article DOI: 10.1021/jm301355j
BindingDB Entry DOI: 10.7270/Q2XK8GWB
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
PDB
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n/an/a 1.10E+3n/an/an/an/an/a25



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...


J Med Chem 56: 1772-6 (2013)


Article DOI: 10.1021/jm301355j
BindingDB Entry DOI: 10.7270/Q2XK8GWB
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
PDB
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Article
PubMed
n/an/a 158n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1)


J Med Chem 33: 992-8 (1990)


Article DOI: 10.1021/jm00165a017
BindingDB Entry DOI: 10.7270/Q2WW7GNM
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50015094
PNG
(CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...)
Show SMILES ONC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)
PDB
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Article
PubMed
n/an/a>3.33E+4n/an/an/an/an/a25



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...


J Med Chem 56: 1772-6 (2013)


Article DOI: 10.1021/jm301355j
BindingDB Entry DOI: 10.7270/Q2XK8GWB
More data for this
Ligand-Target Pair