BDBM50049394 5,4'-Dihydroxy-6,7-dimethoxyflavone::5-Hydroxy-2-(4-hydroxy-phenyl)-6,7-dimethoxy-chromen-4-one::5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-chromen-4-one::CHEMBL348436::Cirsimaritin::cid_188323::cirsimartin

SMILES COc1cc2oc(cc(=O)c2c(O)c1OC)-c1ccc(O)cc1

InChI Key InChIKey=ZIIAJIWLQUVGHB-UHFFFAOYSA-N

Data  6 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50049394   

TargetAdenosine receptor A1(Rattus norvegicus (rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of specific [3H]-PIA binding from adenosine A1 receptor in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataKi:  1.20E+3nMAssay Description:Ability to displace [3H]N6-phenylisopropyladenosine binding from adenosine A1 receptor.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataKi:  1.72E+3nMAssay Description:Displacement of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataKi:  3.00E+3nMAssay Description:Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataKi:  3.02E+3nMAssay Description:Ability to displace [3H]-CGS- 21680 binding from adenosine A2A receptor.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataKi:  3.16E+3nMAssay Description:Ability to displace [125I]-AB-MECA binding from adenosine A3 receptor.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataIC50:  430nMAssay Description:Inhibition of porcine DPP4 after 30 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil cytosol factor 1 [S99G](Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataIC50:  5.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Susan Smith, Emory Univers...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-acyl-carrier protein reductase(Plasmodium falciparum)
University Of Zurich

Curated by ChEMBL
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of FabGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Inifta (Unlp, Cct La Plata-Conicet)

Curated by ChEMBL
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of rat lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50049394(5,4'-Dihydroxy-6,7-dimethoxyflavone | 5-Hydroxy-2-...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of rat cortex homogenate AChE using acetylthiocholine iodide as substrate after 15 mins in presence of BuChE inhibitor iso-OMPA by Ellman'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed