BDBM50059282 CHEMBL3393453

SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CC4CCOC4C3)c12

InChI Key InChIKey=GQERVRMWWVZZDB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50059282   

LigandChemical structure of BindingDB Monomer ID 50059282BDBM50059282(CHEMBL3393453)
Affinity DataIC50: 139nMAssay Description:Inhibition of GST-tagged truncated human recombinant LRRK2 using fluorescein-labeled LRRKtide peptide substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50059282BDBM50059282(CHEMBL3393453)
Affinity DataIC50: 626nMAssay Description:Inhibition of human recombinant MST2 using Ser/Thr peptide 7 substrate after 45 mins by Z-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50059282BDBM50059282(CHEMBL3393453)
Affinity DataIC50: 3.69E+3nMAssay Description:Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 26(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50059282BDBM50059282(CHEMBL3393453)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of human recombinant MST4 using Ser/Thr peptide 7 substrate after 60 mins by Z-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed