BDBM50082998 (2R,3S)-2-(4-Benzyloxy-butyl)-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-3-(1-methyl-2-oxo-1,2-dihydro-quinazolin-6-ylmethoxy)-succinamide::CHEMBL148331

SMILES CNC(=O)[C@@H](NC(=O)[C@H](CCCCOCc1ccccc1)[C@H](OCc1ccc2n(C)c(=O)ncc2c1)C(=O)NO)C(C)(C)C

InChI Key InChIKey=VOXBFNGVFFRNIE-FXVJXKIMSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50082998   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50082998((2R,3S)-2-(4-Benzyloxy-butyl)-N*1*-((S)-2,2-dimeth...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50082998((2R,3S)-2-(4-Benzyloxy-butyl)-N*1*-((S)-2,2-dimeth...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of TNF(tumor necrosis factor) in human bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50082998((2R,3S)-2-(4-Benzyloxy-butyl)-N*1*-((S)-2,2-dimeth...)
Affinity DataIC50:  730nMAssay Description:Inhibitory activity against MMP-1 (Matrix metalloproteinase-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed