BDBM50101866 2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-carboxamidine::CHEMBL52427

SMILES Cc1cc(-c2cc3cc(ccc3[nH]2)C(N)=N)c(O)c(c1)-c1ccccc1

InChI Key InChIKey=ALBWLRSLXFJFTE-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50101866   

TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  38nMAssay Description:Inhibitory concentration against Human Serine Protease Urokinase Plasminogen ActivatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  110nMAssay Description:Inihibtion of Human Serine Protease tissue type Plasminogen ActivatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  110nMAssay Description:Inhibitory activity against urokinase-type plasminogen activator (microPa) in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  130nMAssay Description:Activity against Human Serine Protease TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  210nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  250nMAssay Description:Inhibition of Human Serine Protease PlasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  640nMAssay Description:Inhibitory activity against Coagulation factor X in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  1.10E+3nMAssay Description:Activity against Human Serine Protease ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibitory activity against plasmin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibitory activity against trypsin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50101866(2-(2-Hydroxy-5-methyl-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibitory activity against thrombin(fIIa) in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed