BDBM50117775 CHEMBL84894::N-(4'-Chloro-biphenyl-4-ylmethyl)-N-dimethylcarbamoylmethyl-2-[2-(4-fluoro-benzylsulfanyl)-5-(2-methoxy-pyrimidin-5-ylmethyl)-4-oxo-4H-pyrimidin-1-yl]-acetamide

SMILES COc1ncc(Cc2cn(CC(=O)N(CC(=O)N(C)C)Cc3ccc(cc3)-c3ccc(Cl)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1

InChI Key InChIKey=QBBSJLRQRYQJOI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50117775   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117775(CHEMBL84894 | N-(4'-Chloro-biphenyl-4-ylmethyl)-N-...)
Affinity DataIC50: <500nMAssay Description:Inhibition of cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117775(CHEMBL84894 | N-(4'-Chloro-biphenyl-4-ylmethyl)-N-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed