BDBM50123975 3-[4-(biphenyl-4-sulfonylamino)-phenyl]-N-hydroxy-acrylamide::CHEMBL145891::US8796330, 120

SMILES ONC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)cc1

InChI Key InChIKey=CITNMKKLNPYCDV-OVCLIPMQSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50123975   

TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

US Patent
LigandPNGBDBM50123975(3-[4-(biphenyl-4-sulfonylamino)-phenyl]-N-hydroxy-...)
Affinity DataIC50:  10nMT: 2°CAssay Description:For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

US Patent
LigandPNGBDBM50123975(3-[4-(biphenyl-4-sulfonylamino)-phenyl]-N-hydroxy-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Aton Pharma

Curated by ChEMBL
LigandPNGBDBM50123975(3-[4-(biphenyl-4-sulfonylamino)-phenyl]-N-hydroxy-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

US Patent
LigandPNGBDBM50123975(3-[4-(biphenyl-4-sulfonylamino)-phenyl]-N-hydroxy-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity on partially purified recombinant human Histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed