BDBM50139391 (R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)benzonitrile::4-{2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl}-benzonitrile::ABT-239::CHEMBL351231
SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C#N
InChI Key InChIKey=KFHYZKCRXNRKRC-MRXNPFEDSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 40 hits for monomerid = 50139391
Affinity DataKi: 0.400nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.447nMAssay Description:Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Displacement of [3H]N-alpha methyl histamine from human cloned histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Displacement of [3H]-N-alpha methyl histamine from human H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.23nMAssay Description:In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 1.35nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.35nMAssay Description:Displacement of [3H]-N-alpha methyl histamine from rat H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.35nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from rat cloned histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [3H]-NAMH from rat histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 3.22nMAssay Description:Displacement of [3H]N-alpha methyl histamine from rat cortical membrane histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.22nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in rat cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Displacement of [3H]RAMH from human histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.57nMAssay Description:Antagonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as inhibition of RAMH-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataKi: 9.10nMAssay Description:Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 9.10nMAssay Description:Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 31nMAssay Description:Displacement of [3H]NAMH from rat histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 17.4nMAssay Description:Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 1.29nMAssay Description:Agonist activity at human histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.630nMAssay Description:Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...More data for this Ligand-Target Pair