BDBM50163795 CHEMBL3798382
SMILES Cn1ncc2cc(ccc12)-c1cnc(N)c(Cl)c1N1CCC2(CCNC2=O)CC1
InChI Key InChIKey=VPJXPDLMACOGIZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50163795
Affinity DataKi: 11nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin) using RBER-CHKtide as substrate in presence of [32P]gammaATP incubated for 60 mins by microplate scintil...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human CDK8 in human Jurkat cells assessed as inhibition of STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Binding affinity to human CDK8 (1 to 464 amino acid residues)/Cyclin C (1 to 283 amino acid residues) by reporter displacement assayMore data for this Ligand-Target Pair