BDBM50165771 (R)-7-Benzyl-2-bromo-5-ethyl-3-(4-hydroxy-benzyl)-7,8-dihydro-3H,5H-imidazo[2,1-b]purin-4-one::CHEMBL373102

SMILES CCN1C2=N[C@H](Cc3ccccc3)CN2c2nc(Br)n(Cc3ccc(O)cc3)c2C1=O

InChI Key InChIKey=HVDQYPSFEUUGDN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50165771   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165771((R)-7-Benzyl-2-bromo-5-ethyl-3-(4-hydroxy-benzyl)-...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165771((R)-7-Benzyl-2-bromo-5-ethyl-3-(4-hydroxy-benzyl)-...)
Affinity DataIC50: 540nMAssay Description:Inhibition of human phosphodiesterase 11More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165771((R)-7-Benzyl-2-bromo-5-ethyl-3-(4-hydroxy-benzyl)-...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory concentration against human phosphodiesterase 10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165771((R)-7-Benzyl-2-bromo-5-ethyl-3-(4-hydroxy-benzyl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165771((R)-7-Benzyl-2-bromo-5-ethyl-3-(4-hydroxy-benzyl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Phosphodiesterase 9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed