BDBM50166940 NP-031112::NP-12::Tideglusib::US20230414581, Compound 7::med.21724, Compound 155
SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1
InChI Key InChIKey=PMJIHLSCWIDGMD-UHFFFAOYSA-N
Data 20 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 22 hits for monomerid = 50166940
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant GSK3beta expressed in Escherichia coli using GS-1 as substrate incubated for 20 mins by gamma[32P]ATP-based scintilla...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+3nMAssay Description:Recombinant SARS-CoV-2 Mpro with native N and C termini was expressed in Escherichia coli, and subsequently purified (Extended Data Fig. 1a, b). The ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Primary assay principle based on quenched FRET peptide substrate of SARS-CoV-2 3CL-Pro (lhs). Inhibiting compounds reduce fluorescence signal relativ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of Staphylococcus aureus SrtA delta N24 mutant expressed in Escherichia coli BL21 (DE3) assessed as reduction in IsdA (64 to 323 residues)...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of Staphylococcus aureus SrtA delta N24 mutant expressed in Escherichia coli BL21 (DE3) using Abz-LPATG-Dnp substrate incubated for 20 min...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+3nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant GSK3beta using GSK3 peptide as substrate preincubated for 15 mins followed by ATP addition and measured after 90 mins...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Affinity DataIC50: 139nMAssay Description:Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of SARS-CoV-2 M-proteaseMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+3nMAssay Description:First, 200 μM of the compound was added to a 50 mM Tris-HCl (pH 7.5) solution containing 0.05 μg/ml dN-SARM1. Then half of the mixture was ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of SARS-CoV-2 MPro expressed in Escherichia coli BL21 (DE3) using Mca-AVLQ SGFR-K(Dnp)K as substrate by EnVision multimode plate reader an...More data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of SARS CoV-2 main protease using DABCYL-KTSAVLQSGFRKM-E(EDANS)-NH2 as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Affinity DataIC50: 251nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
Affinity DataIC50: 670nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Centro De Investigaciones Biologicas (Cib, Csic)
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair