BDBM50168484 CHEMBL3805137::US9765060, Compound Y

SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=UUBRXVROYUUZMP-LBPRGKRZSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50168484   

LigandPNGBDBM50168484(CHEMBL3805137 | US9765060, Compound Y)
Affinity DataIC50:  0.400nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM50168484(CHEMBL3805137 | US9765060, Compound Y)
Affinity DataIC50:  0.400nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50168484(CHEMBL3805137 | US9765060, Compound Y)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168484(CHEMBL3805137 | US9765060, Compound Y)
Affinity DataIC50:  2.03E+3nMAssay Description:Inhibition of human full length PI3K p110alpha/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168484(CHEMBL3805137 | US9765060, Compound Y)
Affinity DataIC50:  154nMAssay Description:Inhibition of human full length PI3Kgamma using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168484(CHEMBL3805137 | US9765060, Compound Y)
Affinity DataIC50:  54nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed