BDBM50178216 CHEMBL3814920::US10206931, Example 131

SMILES C[C@@H]1CC(=O)Nc2ccccc2N1

InChI Key InChIKey=BBPWQLMHOSRDMA-SSDOTTSWSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50178216   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178216(CHEMBL3814920 | US10206931, Example 131)
Affinity DataIC50:  2.60E+5nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD4 bromodomain-1 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178216(CHEMBL3814920 | US10206931, Example 131)
Affinity DataIC50:  2.70E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Jilin University

Curated by ChEMBL
LigandPNGBDBM50178216(CHEMBL3814920 | US10206931, Example 131)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human His-FLAG tagged CBP/EP300 (1082 to 1197 residues) using H4-TetraAc-biotin peptide as substrate after 90 mins by AlphaLISA methodMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50178216(CHEMBL3814920 | US10206931, Example 131)
Affinity DataIC50: >1.97E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178216(CHEMBL3814920 | US10206931, Example 131)
Affinity DataIC50:  2.13E+3nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair