BDBM50206009 CHEMBL3983039::US10280165, Example 35

SMILES Cc1ccc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1[C@@H]1C[C@H]1C#N

InChI Key InChIKey=PXLJMGCNGCDJTO-CMPLNLGQSA-N

Data  4 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50206009   

TargetGlutamate receptor 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50206009(CHEMBL3983039 | US10280165, Example 35)
Affinity DataEC50:  3.10E+4nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50206009(CHEMBL3983039 | US10280165, Example 35)
Affinity DataEC50:  77nMAssay Description:TBDMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50206009(CHEMBL3983039 | US10280165, Example 35)
Affinity DataEC50:  41nMAssay Description:Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...More data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50206009(CHEMBL3983039 | US10280165, Example 35)
Affinity DataEC50:  3.10E+4nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed