BDBM50237501 CHEMBL4071551::US10836758, Example 15

SMILES Fc1cc(NCC2CNC2)c(Cl)cc1S(=O)(=O)Nc1nccs1

InChI Key InChIKey=UJNZKASOHZSXKG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50237501   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50237501(CHEMBL4071551 | US10836758, Example 15)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human CYP3A4 assessed as inhibition of dealkylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50237501(CHEMBL4071551 | US10836758, Example 15)
Affinity DataIC50:  394nMAssay Description:hNaV1.7 binding affinities were determined with a filtration binding assay using purified membranes from HEK293 cells stably expressing hNaV1.7. HEK2...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50237501(CHEMBL4071551 | US10836758, Example 15)
Affinity DataIC50:  339nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current at -60 mV holding potential measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50237501(CHEMBL4071551 | US10836758, Example 15)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human Nav1.5 expressed in HEK293 cells assessed as reduction in peak inward current at -50 mV holding potential measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed