BDBM50240972 5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-(3-methyl-but-2-enyl)-chromen-4-one::8-prenylapigenin::CHEMBL371562

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc(-[#8])c2c1oc(cc2=O)-c1ccc(-[#8])cc1

InChI Key InChIKey=MEHHCBRCXIDGKZ-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50240972   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
University Of Milan

Curated by ChEMBL
LigandPNGBDBM50240972(5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-(3-methyl-but...)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of human recombinant PDE5A1 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240972(5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-(3-methyl-but...)
Affinity DataEC50:  50nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240972(5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-(3-methyl-but...)
Affinity DataEC50:  3.5nMAssay Description:Estrogenic activity at ERbeta (unknown origin) expressed in human MDA-MB-231/beta41 cells after 18 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50240972(5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-(3-methyl-but...)
Affinity DataIC50:  630nMAssay Description:Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed