BDBM50244569 AP24283::CHEMBL510893::N-(4-(dimethylphosphoryl)phenyl)-9-(2-(5-methyl-1H-indazol-4-yl)vinyl)-9H-purin-6-amine::N-[4-(dimethylphosphoryl)phenyl]-9-[(E)-2-(5-methyl-1H-indazol-4-yl)ethenyl]-9H-purin-6-amine

SMILES Cc1ccc2[nH]ncc2c1\C=C\n1cnc2c(Nc3ccc(cc3)P(C)(C)=O)ncnc12

InChI Key InChIKey=UNPSONVHRMUXFE-ZHACJKMWSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50244569   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM50244569(AP24283 | CHEMBL510893 | N-(4-(dimethylphosphoryl)...)
Affinity DataIC50: <0.5nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM50244569(AP24283 | CHEMBL510893 | N-(4-(dimethylphosphoryl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244569(AP24283 | CHEMBL510893 | N-(4-(dimethylphosphoryl)...)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM50244569(AP24283 | CHEMBL510893 | N-(4-(dimethylphosphoryl)...)
Affinity DataIC50: <0.460nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
TargetIsoform 1 of Fibronectin (1)(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM50244569(AP24283 | CHEMBL510893 | N-(4-(dimethylphosphoryl)...)
Affinity DataIC50: <0.5nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed